introduction: multiple sclerosis (ms) is a progressive and autoimmune neurodegenerative disease of the central nervous system (cns). this disease is renowned through symptoms like inflammation, demyelination and the damage of neurological actions. melittin is one of components of bee venom and has anti-neuroinflammatory effects. curcumin also, a dietary spice from turmeric, has outstanding anti...

objective(s):experimental allergic encephalomyelitis (eae) is an autoimmune disease validated as animal model of multiple sclerosis (ms). administration of genistein, a phytoestrogenic component of soy, to mice at the onset of eae is known to attenuate the clinical signs of the disease. the potential effects of genistein on established eae is less studied. in the current study, we aimed to comp...

basic research on the autoimmune disease multiple sclerosis has been performed mainly on its animal model namely experimental allergic encephalomyelitis. there are many different approaches established to get this model. despite the existence of many references in literature in this regard, we have been faced with many difficulties generating the model suitable for studying different therapies....

experimental  allergic encephalomyelitis (eae) is considered  as the murine model of multiple sclerosis. daidzein a phytostrogenic compound of soy is known to impose immunomodulatory and antioxidative effects. we conducted this study to assess the potential protective and therapeutic effects of daidzein on allergic encephalomyelitis. c57bl/6 mice  were induced  with  allergic encephalomyelitis ...

It has previously been reported that synthetic peptides corresponding to sequences derived from T-cell receptor variable regions identified as dominant in the T-cell-mediated autoimmune disease experimental allergic encephalomyelitis in both the mouse and the rat can down-regulate disease in Lewis rats. In contrast to these results, we have found that immunization of Lewis rats with such peptid...

multiple sclerosis (ms) is a progressive and autoimmune neurodegenerative disease of the central nervous system (cns). this disease is recognized through symptoms like inflammation, demyelination and the destruction of neurological actions. experimental allergic encephalomyelitis (eae) is a widely accepted animal model for ms. eae is created in animals by injecting the tissue of myelin basic pr...

Experimental allergic encephalomyelitis is a mouse model of human multiple sclerosis with similar pathology and pathogenesis. Th1 cells play an important role in the pathogenesis of experimental allergic encephalomyelitis. This study determined the potential effect of programmed cell death 1 ligand 1 in the pathogenesis of experimental allergic encephalomyelitis induced by injecting myelin olig...